纳洛酮早期治疗37例急性颅脑损伤的临床疗效观察

Clinical observation of early curative effect of Naloxone on 37 acute craniocerebral trauma patients

目的 观察早期应用纳洛酮对急性颅脑损伤的治疗效果。方法 采用分组对照 ,将 73例重型颅脑损伤患者随机分成两组 ,一组用常规治疗 ,另一组在常规治疗基础上加用纳洛酮 0 .4mg/hr静注 ,连用 7天停药 ,观察患者呼吸 ,心率变化、意识恢复时间 ,脑水肿改变 ,主要症状改善和远期疗效 ,进行统计学分析。结果 纳洛酮治疗组患者意识恢复时间较对照组缩短 ,呼吸、循环较快恢复稳定 ,伤后 1周内患者脑水肿明显减轻 ,伤后 3个月恢复良好率显著高于对照组 ,重残及病死率明显降低。结论 应用纳洛酮早期治疗急性颅脑损伤可以减轻脑水肿 ,缩短昏迷时间 ,降低伤残率及病死率 。

Objective To observe early clinically curative effect of naloxone on acute craniocerebral trauma.Methods 73 patients were divided into two groups randomly.36 patients had been treated on routine treatment and 37 patients had been treated with naloxone except for routine. Trial group were injected with naloxone transvenously by 0.4mg/hr to maintain for one week. Respiration, heart rhythm,the time of conscious recovery, cerebral edema, major symptom improvement and long-term effect were observed.The changes of data were analyzed statistically.Results Clinical observation demonstrated that patients treated by naloxone could shorten the time of conscious recovery as well as respiration, circulation recovered stable quickly. Cerebral edema apparently relieved in one week after brain injury. The rate of recovery in trial group significant higher than that of control group. While severe disablement and fatality rate were less than that of control group.Conclusions Early treatment with application of naloxone for acute craniocerebral trauma can relieve traumatic brain edema and improved the recovery of coma and reduce the disability and fatality rate, so it improved patients' quality of life.