乙型肝炎患者甲状腺激素水平及其临床意义

Thyroid hormone levels in hepatitis B patients and their clinical significance

目的 :探讨不同病程乙型肝炎 (乙肝 )患者甲状腺激素水平变化的临床意义。方法 :用放射免疫法测定 83例不同病程乙肝患者、3 2例非乙肝传染病患者以及 3 7例健康人的血清三碘甲状腺原氨酸 (T3)、甲状腺素 (T4 )、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素 (FT4 )和促甲状腺激素 (TSH)的水平 ,并作统计分析。结果 :急性乙肝患者T4 、FT4 水平升高 ,慢性乙肝患者FT3、FT4 、TSH水平降低 ,肝硬化患者T3、FT3、TSH水平降低 ,重症肝炎患者T3、FT3、FT4 、TSH水平降低。结论

Objective To investigate the change and the clinical significance of serum thyroid hormone levels in the patients of different durations of hepatitis B.Methods Serum concentrations of T 3, T 4, FT 3, FT 4, TSH were detected with radioimmunoassay (RIA) in 83 patients with different durations of hepatitis B, 32 patients with non-hepatitis B infectious diseases and 37 normal controls. Results Serum T 4 and FT 4 levels increased in patients with acute hepatitis B. Levels of FT 3, FT 4 and TSH decreased in patients with chronic hepatitis B. The concentrations of serum T 3, FT 3 and TSH decreased in patients with liver cirrhosis. Serum T 3, FT 3, FT 4 and TSH levels decreased in severe hepatitis patients. Conclusion Determining the concentrations of serum thyroid hormone might be used as an assistant index in evaluating the status of hepatitis B and the prognosis of the patients.