体描仪测定哮喘儿童和成人肺功能的临床意义

Clinical significance of testing pulmonary function with auto-body plethysmograph in children and adults with asthma

目的 :探讨人体体积描记仪 (人体体描仪 )测定哮喘儿童和成人肺功能的临床意义。方法 :采用人体体描仪测定哮喘发作期儿童及成人治疗前后的肺功能 ,比较第 1秒用力呼气容积 (FEV1 )、用力呼气肺活量 (FVC)、第 1秒用力呼气容积占用力呼气肺活量比值 (FEV1 /FVC)、最大呼气流量 (PEF)和用力呼气 2 5 %、5 0 %肺活量时瞬间流量 (FEF2 5% 、FEF50 % )等肺功能指标的变化幅度。结果 :治疗前儿童和成人组PEF异常率分别为 92 .5 8%和 86.3 6% ,治疗后上述指标均有不同程度提高 ,差异显著 (均为P <0 .0 0 1) ;两组间肺功能变化幅度除PEF(P >0 .0 5 )外 ,FVC、FEV1 、FEV1 /FVC、FEF2 5% 、FEF50 % 差异均有显著性(均为P <0 .0 1)。结论 :采用人体体描仪进行肺功能测定有利于哮喘诊断和发作期病情评估 。

Objective To evaluate the clinical significance of pulmonary function with auto-body plethysmograph in children and adults with asthma.Method The pulmonary function of pretherapy and of post-treatment was evaluated with auto-body plethysmograph in children and adults with asthma, and the changes of forced expiratory volume in 1 sec (FEV 1),forced vital capacity (FVC),FEV 1/FVC,peak expiratory flow(PEF),forced mid-expiratory flow rate (FEF 25%,FEF 50%) were measured. Results 25 of 27 cases in children(92.58%) and 19 case of 22 adults (86.36%) were abnormal in PEF before treatment. The values of FEV 1,FVC,FEV 1/FVC,FEF 25%,FEF 50% in post-treatment in both groups were increased significantly(P<0.01). Conclusion Determination on pulmonary function by auto-body plethysmograph is valuable on the diagnosis and treatment of asthma.