珍珠梅水提物对大鼠肝损伤的保护作用

Studies on liver-protection of Sorbaria sorbifolia aqueous extract

目的:研究珍珠梅水提物的保肝作用。方法:给动物灌胃给药,用CCl_4,D-半乳糖造大鼠急性肝损伤模型,用比色分析法测定大鼠血清天冬氨酸转氨酶(aspartate transaminase,ALT)、丙氨酸转氨酶(alaninetransaminase,AST)的活性;测定大鼠血清超氧化歧化酶(superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathione perioxidase,GSH-Px)的活性及丙二醛(malondialdehyde,MDA)的含量。结果:珍珠梅水提物显著降低因CCl_4,D-半乳糖所致急性肝损伤大鼠血清ALT,AST的升高;对急性肝损伤大鼠血清SOD,GSH-PX的活性有明显的升高作用及降低MDA的含量。结论:珍珠梅水提物对CCl_4,D-半等糖所致大鼠急性肝损伤有保护作用。

AIM: To study the liver-protection effects of Sorbaria sorbifolia aqueous extract. METHODS: Sorbaria sorbifolia was perfused into stomach of the rats with liver injury induced by carbon tetrachloride and D-galactosamine. The activities of serum aspartate transaminase (AST), alanine transaminase (ALT), super- oxide dismutase (SOD), glutathione perioxidase (GSH-PX), and malondialdehyde (MDA) were investigated by using colorimetric method. RESULTS: The aqueous extract of Sorbaria sorbifolia sig- nificantly reduced serum ALT and AST in acute liver-injury induced by carbon tetrachloride and D-galactosamine, the activities of SOD and GSH-PX were signficantly higher in treated group than that in model group, and the MDA content in treated group was lower than that in model group. C0NCLUSION: The aqueous extract of Sorbaria sorbifolia has protecting effects for rats with acute hepatic injury induced by carbon tetrachloride and D-galactosamine.