氟西汀与阿米替林治疗躯体形式障碍的对照研究

A comparative study of fluoxetine and amitriptyline in the treatment of somatoform disorders.

目的 探讨氟西汀对躯体形式障碍的临床疗效及副反应。方法 采用随机分组的方法 ,将符合CCMD 3标准的 6 3例躯体形式障碍患者分为氟西汀组 (33)例、阿米替林组 (30 )例 ,治疗 6周 ,用HAMD和TESS评定两组药的疗效及副反应。结果 氟西汀与阿米替林疗效相当 ,但在副反应方面差异有显著性 ,氟西汀副反应轻微。结论 氟西汀治疗躯体形式障碍安全、有效 。

Objective To study the clinical effects and side effects of fluoxetine in treatment of somatoform disorders.Methods Sixty three patients who met CCMD-3 for somatoform disorders were randomly assigned to fluoxetine (33 patients) and amitriptyline (30 patients) treatment for 6 weeks.The clinical effects and side effects were tested with HAMD and TESS.Results Fluoxetine and amitriptyline were similar in clinical effects.The fluoxetine had less side effects than amitriptyline (P<0.01).Conclusion Fluoxetine has better efficacy and less side effects for somatoform disorders.