摘要
目的 评价帕罗西汀治疗广泛性焦虑症的临床疗效和副反应。方法 对 5 6例符合CCMD - 3诊断标准的广泛性焦虑症患者 ,分别应用帕罗西汀 (2 8例 )、地西泮 (2 8例 )进行治疗 ,疗程 4周。采用焦虑自评量表 (SAS)、Hamilton焦虑量表 (HAMA)和副反应量表 (TESS)评定疗效和副反应。结果 帕罗西汀与地西泮对广泛性焦虑症的疗效差异无显著性 (P >0 .0 5 )。治疗第 4周末两组SAS、HAMA以及HAMA因子分的减分比较差异有非常显著性 (P <0 .0 1)。副反应两药相似 ,帕罗西汀的主要副反应为口干、头痛、头晕和恶心。结论 帕罗西汀治疗广泛性焦虑症有效 。
Objective To evaluate the efficacy and side effects of paroxetine in the treatment of generalized anxiety disorder.Methods Fifty six patients who met the criteria of CCMD-3 for generalized anxiety disorder were assigned to paroxetine or diazepam treatment for 4 weeks.The efficacy and side effects were assessed by HAMD,SAS and TESS.Results Paroxetine was similar to diazepam in efficacy,and there was no significant difference between two groups.Both groups showed significant improvement in scores of SAS and HAMA.Two drugs were similar in side effects,and the main side effects of paroxetine were dry mouth,headache,dizziness and nausea.Conclusion Paroxetine was an effective drug with fewer side effects for the treatment of generalized anxiety disorder.
出处
《山东精神医学》
2003年第4期206-207,共2页
Shangdong Archives of Psychiatry