摘要
作者在构建连锁图谱时,发现Newton-Raphson迭代求解似然方程组,即便纳入合子和配子选择因子,各基因型的估计值仍不能很好的接近实测值。本文提出了一种偏分离遗传标记作图的通用最大似然模型。
In the construction of linkage map, authors find that, it can not approach to the real data properly for the estimation recombination fractions between two makers with Newton-Raphson iteration method even ML equation systems considering zygotic and gametic selector. An Universal MLE model for mapping of genetic markers showing segregation distortion is presented.
出处
《生物数学学报》
CSCD
2003年第3期369-377,共9页
Journal of Biomathematics
基金
国家863计划(101-01-01-01-3)
国家自然科学基金(39870421)
