1Moore R D, Lietman P S, Smith C R. Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration [J]. J Infect Dis, 1987,155( 1 ) :93.
2Kashuba A D, Nafziger A N, Drusano G L, et al. Optimizing amino-glycoside therpy for nosocomial pneumonia caused by gram- negative bacteria [J]. Antimicrob Agents Chemother, 1999,43(3) :623.
3Burgess D S. Pharmacodynamic principles of antimicrobial therapy in the prevention of resistance [J]. Chest, 1999, 115(Suppl 3):19S.
4Barclay M L, Begg E J. Aminoglycoside adaptive resistance: importance for effective dosage regimens [J]. Drugs ,2001,61(6) :713.
5Daikos G L, Jackson G G, Lolans V T, et al. Adaptive resistance to aminoglycoside antibiotics from first - exposure down - regulation [J]. J Infect Dis, 1990,162(2) :414.
6Craig W A, Vogelman B. The postanfibiofie effect [ J ]. Ann Intern Med, 1987,106(6) :900.
7Craig W A, Redington J, Ebert S C. Pharmacodynamics of amikacin in vitro and in mouse thigh and lung infections [ J ]. J Antimicrob Chemother, 1991,27(suppl C) :29.
8Mcgrath B J, Marchbanks C R, Gilbert D, et al . In vitro postandbiotic effect following repeated exposure to imipenem, temafloxacin,and tobramycin [ J ]. Antimicrob Agents Chemother, 1993,37 ( 8 ) :1723.
9Majtanova L, Majtan V. Postantibiotic effects of gentamicin and netilmicin on Serratia marcescens: effects on hydrophobicity and motility [J]. Folia Microbiol (Praha) ,2000,45(1) :45.
10Kaloyanides G J. Drug- phospholipid interactions: role in amino-glycoside nephrotoxicity [J]. Ren Foil, 1992,14(3) :351.
