丹参与三七配伍对大鼠慢性肝损伤的作用

Effects of compatibility of Salvia miltiorrhiza Bge and Panax notoginseng on chronic liver injury in rats

目的 :观察丹参与三七配伍对慢性肝损伤的治疗作用。方法 :采用 CCl4 复制大鼠慢性肝损伤模型 ,测定血清丙氨酸氨基转移酶 (AL T)、白蛋白、球蛋白、透明质酸 (HA)、层粘连蛋白 (L N)、肝组织羟脯氨酸 (Hyp)含量 ,以反映肝细胞损伤及肝纤维化程度 ,并进行肝脏病理组织学检查。结果 :丹参与三七配伍治疗后肝细胞损害、肝脏脂肪变性、炎细胞浸润的程度均较轻 ,成纤维细胞和胶原纤维增生亦较少。结论 :丹参与三七配伍对损伤肝病组织的修复 。

Objective: To observe whether Salvia miltiorrhiza Bge is compatible with Panax notoginseng in chronic liver injury in rats. Methods: Chronic liver injury rat model was prepared by CCl 4.Levels of serum alanine aminotransferase (ALT), albumin, globulin, hyaluronic acid (HA) and laminin (LN) and hydroxyproline(Hyp) in the liver tissue were determined to reveal the extent of liver damage, The hepatic histomorphology was examined by HE staining. Results: The extent of liver damage, fatty degeneration and infiltration of inflammatory cells were less severe in Salvia miltiorrhiza Bge compatible with Panax notoginseng group than in the CCl 4 group. The formation of fibroblasts and collagenous fibers was less in Salvia miltiorrhiza Bge compatible with Panax notoginseng group than in the CCl 4 group. Conclusion: Salvia miltiorrhiza Bge compatible with Panax notoginseng had better effects on the recovery of impaired hepatic organization and promoted liver cell regeneration.