859例原发培阳肺结核全程督导短程化疗效果与耐药性分析

Analysis of the Relationship between Drug Resistance and Short Course Chemotherapy Effect in 859 Initial Culture Positive Pulmonary Tuberculosis

目的 分析 85 9例原发培阳肺结核病人其耐药性与全程督导短程化疗 (DOTS)效果的关系。方法 药敏试验采用比例法 ,培养基中药物浓度分别为 S4 μg/ m l、H0 .2 μg/ m l、R4 0 μg/ ml和 E2 μg/ ml;病人治疗采用卫 项目统一规定的全程间歇短化方案 (2 S3H3R3/ 4 H3R3)。结果 85 9例病人经 6个月的治疗后 ,除 8例失访外 ,其中治愈 771例 (89.8% ) ,完成治疗 6 7例 (7.8% ) ,失败 9例 (1 .0 % )。化疗失败病人耐单药和耐二药组与敏感组无显著性差异 (P>0 .0 5 )。结论 对于原发敏感和耐一或二种药物的病例采用

Objective To analyze the relationship between the drug resistance and the short course chemotherapy effect in 859 initial culture positive pulmonary tuberculosis. Methods All Susceptibility tests with proportion method (SM 4 μg/ml, INH 0 2 μg/ml,RFP 40 μg/ml, EMB 2 μg/ml) were determined in all cases , The treatment regiment of 859 cases was short course intermittent chemotherapy (2S 3H 3R 3E 3/4H 3R 3) recommended by WHO. Results After having completed 6 month treatment course, except 8 cases defaulted, 771 cases were cured(89 8%), 67 cases completed treatment (7 8%), 9 cases failed (1 0%). There is no significant differece between the failed patients with the three groups (mono drug resistance,2 drug resistance and sensitive cases)(P>0 05). Conclusions It is reasonable and effective to cure drug sensitive and mono or 2 drug resistance cases with short course intermittent chemotherapy.