牛初乳提取物(BCE)对儿童免疫功能影响的探讨

The effect of bovine colostrum extract (BCE) on Immunological function of children susceptible to respiratory tract infection

９０例反复呼吸道感染住院患儿按同年龄、性别、病程、病情 １：１配对，按常规抗感染治疗，试验组加服ＢＣＥ（０．４ｇ／天）。结果表明：反复呼吸道感染小儿存在免疫功能缺陷，试验组小儿服用ＢＣＥ后血清免疫球蛋白ＩｇＧ较前明显上升（Ｐ＜０．０１），Ｔ细胞亚群（ＣＤ３、ＣＤ４）水平上升，ＣＤ８下降（Ｐ＜０．０１），ＣＤ４／ＣＤ８比值提高（Ｐ＜０．０１），呼吸道感染率明显下降（Ｐ＜０．０１）。提示ＢＣＥ可提高易感儿童免疫功能。

Study the mechanisms of bovine colostrum extract in reducing incidence of repeated respiratory tract infection (RRTI). 1:1 matched case-control similar in age, sex, height and severity of the disease were conducted on 45 pairs. Patients group were treated with an oral bovine colostrum extract (0. 4g/d). The serum IgG, IgA, IgM and T cell subgroups (CD3 ,CD4, CD8) were detected in the morbid stage (next day after admittance) and in the recovery stage (third months after admittance). Result disturbance of immunity was involved in RRTI patients. In the recovery stage, the serum IgG was significantly elevated in BCE supplemented patients. The number of CD4 and CD4 /CD8 ratio was signifiantly higher than that in the morbid stage (PK 0. 01) , Incidence of respiratory tract infection was significantly lower than that in morbid stage (P<0. 01) ,and which was not achieved in the control group. Conclusion BCE could improve immune function of RRTI children and could prevent respiratory tract from infection.