摘要
老年黄斑部变性(Senile Macular Degen-eration,SMD)是老年人致盲原因之一,目前对其发病机理尚未完全弄清。Gass 和Chandra等人认为SMD 的发病机理可能是由于脉络膜毛细血管之间基质钙化变性而增厚,以及脉络膜基底膜(Bruch 膜)增厚影响到脉络膜毛细血管床所致。Delaney 等人认为SMD病因可能与老化过程有关。而另外有些人则认为SMD 与遗传和营养不良等疾病有关,不仅仅是老年变性或老化。解剖和生理的研究显示SMD 的改变为视网膜色素上皮和脉络膜的广泛硬化,而某些微量元素则参与了视网膜色素上皮及脉络膜代谢。我们对SMD 患者血清微量元素进行了测定以寻求二者之间的关系。现将结果报导如下。
This paper presents the study of copper,zinc,iron,magnesium and calcium contents in both senile macular degeneration (SMD) and normal human serum.The amounts of these trace elements,20 samples in each group,were measured by atomic absorption spectrophotometry (AAS).After treated bystatistics,the results showed that zinc level was significantly higher (p<0.01) and iron level was muchhigher (p<0. 05)in the samples of SMD than those in the normal group.However,there was no differ-ence about copper,magnesium and calcium contents between two groups.We compared the resultswith those determined by other scientists,and reviewed the role of zinc and some other trace elementsin the metabolism of retina.We believe our study will provide evidences for further research in thisfield.
