别嘌醇研究的新进展

Advances in allopurinol researcch

别嘌醇为次黄嘌呤的异构体。临床上主要用于治疗痛风 ,随着氧自由基学说研究的不断拓展 ,发现别嘌醇能减少缺血再灌注损伤中氧自由基的生成而达到抗氧化的作用 ,故许多研究者把别嘌醇用于治疗心血管、脑、肺、胃肠和肝等部位缺血再灌注的损害 ;另外 ,它还具有扩管作用为治疗慢性心衰提供了新的药物 ;

Allopurinol is a xanthine oxidase inhibitor,it can reduce production and excretion of uric acid and oxygen free radicals generation. Allopurinol has good therapeutic effects on gout and hyperuricemia,and can relief symptoms of prostatitis. In addition, allopurinol has protective effects on ischemical reperfusion injury,inflammation and tumor.