内源性大麻素样物质的可能作用机制

Possible pharmacological mechanisms of endocannabinoids

内源性大麻素样物质是大麻素受体的内源性配体 ,在脑内有其特定的合成、转运、代谢途径 ,在生理状态下可调节某些神经递质如谷氨酸、GABA等的释放。因此对其作用机制的阐明不仅有利于进一步探讨大麻成瘾的机制 。

Endocannabinoids are endogenous brain ligands of cannabinoid receptors and have specific synthesizing,transporting,metabolizing ways in the body. Endocannabinoids can regulate release of some neurotransmitters such as glutamate or GABA. So elucidating the mechanism of endocannabinoids is not only helpful in understanding the mechanisms of cannabiod addicton but also useful in developing new useful drugs.