摘要
目的 :研究唐古特大黄多糖 (RheumtanguticumPolysaccharides ,RTP)对大鼠实验性脑外伤的保护作用。方法 :从青海产唐古特大黄中分离提取大黄多糖。SD大鼠 12 0只分为正常对照组 (6 ,2 4 ,4 8h)、模型组 (6 ,2 4 ,4 8h)和多糖 (10 0 ,2 0 0 ,4 0 0mg·kg-1)治疗组 (6 ,2 4 ,4 8h)共 15组 ,每天灌胃给药 1次 ,5d后 ,复制颅脑坠击伤模型 ,分别在造模后 6 ,2 4 ,4 8h测定脑含水量和脑组织超氧化物歧化酶 (SOD) ,Na+ K+ ATP酶活性 ,以及丙二醛(MDA)水平。结果 :RTP可降低脑损伤后的脑含水量和脑组织丙二醛水平 ,升高脑组织SOD和Na+ K+ ATP酶活性 ,作用持续至 4 8h。结论 :大黄多糖是中药大黄治疗脑损伤的有效成分之一 ,具有神经保护作用。
Objective:To evaluate protective effects of Rheum tanguticum Polysaccharides(RTP) on traumatic brain injury(TBI) in rats. Method: The polysaccharides(RTP) were extracted from Tanguficum Maxim. 120 rats were divided into 15 groups, with 8 rats in each group. RTP at 100,200 and 400 mg·kg -1 were administrated orally once a day for five days,and model of brain injury was made by dropping weight method. Result: RTP reduced water content and malondialdehyde(MDA) levels, and increased total SOD activity and Na +-K + ATPase activity after injuried. Conclusion:The polysaccharides may be one of the effective comptents in Rheum tanguticum , showing significant neuroprotective effects.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2003年第10期974-976,U001,共4页
China Journal of Chinese Materia Medica
基金
国家自然科学基金资助项目 (3 0 0 0 0 2 2 4)
关键词
唐古特
大黄多糖
大鼠
实验性颅脑外伤
保护作用
中药
Rheum tanguticum polysaccharide
traumatic brain injury
Na+-K+ ATPase
malondialdehyde(MDA)
superoxide dismutase(SOD)
