缰核介导刺激岛叶、杏仁中央核引起的升压反应

HABENULA PARTICIPATES THE VASOPRESSOR RESPONSE BY STIMULATION OF THE INSULAR COR TEX,CENTRAL-,LATERAL AMYGDALOID NUCLEUS RESPECTIVELY

目的 :证明缰核 (Hb)是刺激岛叶 (INS)、杏仁中央核 (CeA)所引起的升压效应下行通路的主要中继站之一。方法 :分别电刺激INS、CeA均可引起升压反应 ,在刺激电极的同侧及双侧Hb内微量注射盐酸利多卡因 ,再电刺激INS、CeA观察升压效应。结果 :单侧Hb内注射利多卡因 ,电刺激INS、CeA所引起的升压反应分别降低 36 .9%、39.6 %。双侧Hb内注射利多卡因 ,电刺激INS、CeA所引起的升压反应分别降低 4 1.7%、4 6 .1%。单侧或双侧Hb内微量注射生理盐水或人工脑脊液均不能降低电刺激INS、CeA引起的升压反应。结论 :缰核是介导电刺激岛叶、杏仁中央核引起升压效应下行通路的主要中继站之一。

Aim: To investigate whether if the Habenula is the main relay involved i n the vasopressor effect induced by the stimulus of insular cortex,central-,lat eral amygdaloid nucleus respectively. Methods: Electrostimulatio n of the nuclei mention above respectively,and microinjection of lidocaine into Habenula unilaterally and bilaterally. Results: When INS or CeA was stimulated,inducing an obvious increase of blood pressure. To stimulate INS or CeA after microinjecting lidocaine into Hb 5 minuts,the amplitudes of the v asopressor responses were decreased significantly,and the decrease of the bilat erally was larger(decreased value:41.7% in INS, 46.1% in CeA) than that of unila terally(decreased value:36.9% in INS、39.6% in CeA). Conclusion: Habenula is one of the main relays involved in the vasopressor effects indu ced by the stimulus of insular cortex,central-,lateral amygdaloid nucleus.