冶金行业职工胆石病危险因素的病例对照研究

Case-control study on the risk factors of gallstone disease among the metallurgy workers

目的 探索胆石病的危险因素 ,为人群预防提供依据。方法 选取马钢公司胆系疾病现况调查中发现的 175例胆石病患者为病例组 ,4 2 1例非胆石病者为对照组 ,进行人群病例对照研究 ;采用非条件 logistic回归对 38个变量进行分析。结果 单因素 logistic回归分析发现共有 2 0个变量有统计学意义 ,多因素 logistic回归共有 13个进入模型 ;其中 7个变量为胆石病的危险因素 ,OR值大小依次为 :胆囊炎史、胆石病家族史、油腻饮食、甘油三脂、体质指数、多食动物蛋白和女性孕次 ,而多饮牛奶、按时进早餐、饮酒、多食水果、较高文化程度和多食蔬菜 6个变量为保护因素。结论 胆囊炎、家族史、油腻饮食、高甘油三脂、肥胖、多食动物蛋白、多孕次是胆石病危险因素 ,而多吃蔬菜、水果、按时进早餐、多饮牛奶。

Objective To explore the risk factors of gallstone disease (GD), provide the potential implication for prevention. Methods A population-based case-control study including 175 gallstone disease cases and 421 controls was carried out. A total number of 38 factors were analyzed by unconditional logistic regression. Results Twenty factors were associated with GD based on the logistic regression analysis. Thirteen factors entered the last model of the logistic multivariate regression. Cholecystitis, family history of GD, Oily foods, serum triglycerides, body mass index, the more protein consumption and number of pregnancies were risk factors of GD. More milk, breakfast, alcohol drinking, fruit consumption, higher education background and vegetable were protective factors of GD. Conclusions The main risk factors of GD were cholecystitis, family history of GD, oily foods, serum triglycerides, body mass index, protein consumption and number of pregnancies. Milk, breakfast, alcohol drinking, fruit, higher education background and vegetable were protective factors of GD.