男性2型糖尿病患者肾脏损害与骨质疏松症关系的研究

Relationship between renal damage and osteoporosis in male patients with type Ⅱ diabetes mellitus

目的 探讨男性2型DM患者肾脏损害与骨密度关系。方法应用DEXA测定了96例2型糖尿病(DM)患者(正常白蛋白尿组44例,微量白蛋白尿组27例,临床白蛋白尿组25例)和43例对照组L2-4及股骨近端BMD。结果 微量白蛋白尿期的DM患者BMD有下降趋势,但无统计学差异(P>0.05),临床白蛋白尿期DM患者L2-4、Neck、Ward’s、Troch的BMD显著降低(P<0.01或P<0.05)。结论 肾脏损害是加重男性2型DM患者OP的重要因素。

Objective To investigate the relationship between renal damage and osteoporosis in male patients with type Ⅱ diabetes mellitus. Methods Dual energy X-ray absorptimmetry was used to measure the bone mineral density(BMD) of lumbar spines (L2-4),femoral neck,Ward's triangle and trochanter in 96 patients with type Ⅱdiabetes mellitus (including 44 cases of normoalbuminuria, 27 cases of microalbuminuria and 25 cases of clinical albuminuria)and 43 normal controls. Results The BMD of proximal femoral and lumbar spines in microalbuminuria group was lower than that in normal controls,but had no statistical differences( P > 0.05) .The BMD of Lumbar spines and proximal femur in clinical albuminuria group was lower than that in normal conlrols ( P < 0.01,0.05). Conclusions Renal damage is an important factor in aggravating OP in male patients with type Ⅱdiabetes mellitus.