泼尼松治疗对肾病综合征患儿血清骨钙蛋白和碱性磷酸酶的影响

Effects of prednison on serum osteocalcin and alkaline phosphatase in children with nephrotic syndrome

目的 通过测定。肾病综合征患儿激素不同治疗阶段的血清骨钙蛋白及血清碱性磷酸酶,探讨二者在泼尼松治疗时的内在关系及变化规律。方法 实验分3组:激素治疗前组,激素治疗和对照组。结果 肾病综合征患儿在激素治疗前血清骨钙蛋白水平明显低于对照组(P<0.05),而碱性磷酸酶与对照组相比差异无显著性(P>0.05);应用激素治疗后二者均明显低于激素治疗前组(P<0.05),血清骨钙蛋白水平和血清碱性磷酸酶水平呈正相关(P<0.05)。结论 血清骨钙蛋白和血清碱性磷酸酶都是反映成骨细胞功能活性的指标,激素治疗后患儿的成骨细胞功能受到显著抑制,导致血清骨钙蛋白和碱性磷酸酶水平降低。

Objective To determine serum osteocalcin regularities and alkaline phosphatase in prednison-treated children with nephrotic syndrome, and study their correlations and regularities of change. Methods Ninety-two patients were divided into three groups: before-prednison-treatment group, prednison-treated group and normal group. Results Serum osteoealein ( BGP) levels in before-prednison-treatment group was significantly lower than those in normal group(P < 0.05)while there was no significant difference in serum total alkaline phosphatase between the two groups. In the prednison-treated group,BGP and AKP levels were lower than those in before-predni-son-treatment group(P < 0.05 , P < 0.01, respectively) .There were significant positive correlations between serum BGP and AKP( P < 0.05). Conclusions Both serum BGP and are biochemical markers reflecting osteoblast activity. Osteoblast activity is significantly depressed after prednison treatment, so that serum osteoealein and alkaline phosphatase decreased eventuallv.