1-(2,4-二氯苯基)二甲基2-(1,2,4-三唑-1)-戊烯酮合成工艺

The Processing Condition of 1-(2,4-Dichlorobenzene)Dimethyl 2-(1,2,4-Triazole-1)-Pentenone

1H - 1,2 ,4 -三唑和氯甲特丁酮反应 ,以有机碱作催化剂 ,生成的产物唑酮再与 2 ,4 -二氯苯甲醛进行反应 ,生成 1- (2 ,4 -二氯苯基 )二甲基 2 - (1,2 ,4 -三唑 - 1) -戊烯酮 (简称烯酮 )。试验表明 ,选择不同溶剂、反应时间、催化剂用量影响烯酮的纯度及收率 ,采用乙酸乙酯为溶剂 ,水洗后脱酯所得到的唑酮纯度为 90 .1% ,产率在 90 %以上 ;选用 2ml有机碱催化剂和反应时间15h生成烯酮产率为 93%。

H-1,2,4-triazole reacting with pinacolone,using organic alkali as catalyst,produces triadine,which reacting with 2,4-dichlorobenzalehyde produces 1-(2,4-dichlorobenzene)dimethyl 2-(1,2,4-triazole-1)-pentenone (the abbeviated form of the name is olefine ketone).The tests show that choosing different fluxes,different time and different quantity of catalyst affects the purity and the getting rate of the olefine ketone. Using ethyl acetate as flux,the purity of triadime which is deesterificated after being washed is 90.1% and the producing rate of triadime is above 90%;Choosing 2ml organic alkali as catalyst and setting the reacting time as 15 hours,the producing rate of olefine ketone was 93%.