肝动脉灌注化疗和姑息性胃切除治疗胃癌多发性肝转移患者的疗效比较

Comparison between the effects of hepatic arterial infusion chemotherapy and palliative gastrectomy for gastric cancer with multiple hepatic metastases

目的 评价姑息性胃切除和肝动脉灌注化疗(HAI)对胃癌多发性肝转移患者生存时间的影响。方法 回顾性分析1981年3月至2002年12月间有多发性肝脏转移而无肝外转移的24例胃癌患者的临床资料。其中接受HAI者(HAI组)10例,行姑息性胃切除(姑息切除组)14例。结果两组患者的年龄、性别、肝转移情况、肿瘤部位和分化程度的差异无显著性意义(P>0.05),中位生存期分别为(476±118)d和(202±25)d。HAI组生存时间显著长于姑息切除组(P=0.0198),HAI组和姑息切除组患者1年生存率分别为56.2％和14.6％。结论 对于胃癌多发性肝转移患者,HAI的疗效优于姑息性胃切除。

Objective To evaluate the effects of hepatic arterial infusion(HAI) chemotherapy and palliative gastrectomy for gastric cancer with multiple hepatic metastases. Methods From March 1981 to December 2002, 24 patients with multiple liver melastases from gastric carcinoma, but without peritoneal dissemination, received treatment including HAI in 10 and palliative gastrectomy in 14 cases. The clinical data were analyzed retrospectively. Results There were no significant difference in the background factors such as age, sex, hepatic metastasis and tumor location and differentiation between the two groups. The median survival in HAI and palliative gastrectomy groups were (476±118) days and (202±25) days respeclively( P = 0. 0198) . The 1-year survival rate was 56.2% in HAI group and 14.6% in palliative gaslrectomy group. Conclusions The therapeutical effect of HAI is better than that of palliative gastrectomy. HAI chemotherapy can prolong the survival of patients with multiple liver metastases.