摘要
目的 :探讨瑞美隆与氯丙咪嗪治疗抑郁症患者的疗效与不良反应特点。方法 :随机选取 85例抑郁症患者 ,分别给予瑞美隆与氯丙咪嗪单一治疗 ,并分别于治疗前 ,治疗后第 1、 2、 4、 6周进行汉密尔顿抑郁量表(HAMD) ,临床疗效总评量表 (CGI) ,副反应量表 (TESS)评定。结果 :6周时瑞美隆总显进率为 81 4 % ,明显优于氯丙咪嗪组 (6 1 9% ) (P <0 0 5 ) ;1、 2周时瑞美隆治疗好转率分别为 4 8 8%和 81 4 % ,均分别显著高于同期氯丙咪嗪组 (P <0 0 1和P <0 0 5 ) ,且瑞美隆组HAMD总分第 1周时相对治疗前有显著性差异 (P <0 0 5 )。瑞美隆组TESS分和脱落率显著低于氯丙咪嗪组 ,尤其在口干 ,视物模糊和便秘上均存显著性差异 (P <0 0 1 )。结论 :瑞美隆治疗抑郁症起效快 ,疗效肯定 ,副反应少且轻微 ,依从性好 ,值得在抑郁症患者中广泛应用。
Objective:To compare the efficacy and the safety between the Remeron and Clomipamine on depressions Method 85 patients were randomly treated and compared with Remeron and Clomipramine The HAMD,CGI,TESS were mearsured before the treatment and the 1 st ,2 nd ,4 th and 6 th weekend Result Remeron was significantly superior to reducing HAMD scores at the 1 st,2nd and 6th weekend The percentage of responders was 88 4% is Remeron and 78 6% in Clompramine after the treatment of 6 weeks As early as 1 st weekend,the Remeron group showed faster and statistically significant improvement,but not in the Clompramine group ( P <0 05) The total of HAMD in the Remeron group decrease significantly ( P <0 01) Remeron has a low incidence of antich olinegic,adrenergic and few patients has dry mouth,drowsiness and weight increase Conclusion Remeron has been found to have a good efficacy,and tolerability profile significanty superior to that of Clomipramine and may be expected to play an important role in the clinical treatment of depressed patients
出处
《广州医药》
2003年第6期34-36,共3页
Guangzhou Medical Journal