阴茎原位癌的诊断及治疗

Carcinoma in situ of the penis

目的 提高Bowen病及增殖性红斑的诊治水平。 方法 分析 18例Bowen病及增殖性红斑患者临床病理资料。发病年龄 3 2～ 72岁 ,平均 49岁。病程 3个月～ 3年 ,平均 1.5年。 10例行局部病变切除术或包皮环切术 ,8例电凝治疗。 结果 15例随访 4～ 48个月 ,2例在阴茎头未治疗区出现新的病变 ,外涂 5% 5 氟脲嘧啶软膏治疗治愈后随访 3及 9个月无复发 ;13例治愈无复发。 结论 包括较深层组织的病理活检是鉴别Bowen病或增殖性红斑与阴茎癌以及其他男性外生殖器疾病的关键 ,局部病变手术切除 ,5

ObjectiveTo report 18 cases of Bowen dis ea se and erythroplasia of Queyrat.MethodsClinicopatholog ical data of 18 cases of Bowen disease and erythroplasia of Queyrat were present ed.10 cases (mean age 49 year)underwent circumcision and local resection and 8 c ases electric coagulation.Results15 cases have been fo llowed up for 4～48 months.2 cases had new disease at an untreated area and the o ther 13 have been free of the disease.Recurrence ocurred in 2 were cured with 5% 5-fluorouracil cream external application.ConclusionsThe result of the surgical treatment for Bowen disease and erythroplasia of Qu eyrat is good and an alternative therapy with 5-fluorouracil for external appli cation may be considered.Adequate biopsy including deeper tissue is necessary fo r differential diagnosis between carcinoma in situ and invasive penile carcinoma or a variety of lesions of the male genitalia.