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非病毒载体基因递送系统的研究进展 被引量：2

Nonviral gene delivery systems:the current situation
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摘要 非病毒载体基因递送系统是相对于以病毒为载体的基因递送系统的另一种基因递送系统。具有高安全性、低免疫原性及易于生产的特性。本文就非病毒基因载体的种类、在疾病治疗中的应用前景及存在的主要问题作一综述。 Nonviral gene delivery systems are aeternative to the viral ones,but the latter use virus, which is called bacteriophage, as the gene vectors. Compared with viral gene vectors, nonviral ones have specific properties of high safety and low immunogenicity and are easy to produce. In this article,the application of nonviral gene delivery systems and nonviral gene therapy to various diseases and the problems in the development of commercial products were reviewed and discussed.
作者 孙岚 张英鸽
机构地区 军事医学科学院毒物药物研究所
出处 《军事医学科学院院刊》 CSCD 北大核心 2003年第5期384-387,共4页 Bulletin of the Academy of Military Medical Sciences
基金 军队"十五"计划科研基金重点课题 (0 1Z0 2 4)
关键词 非病毒载体基因递送系统 研究进展 非病毒载体基因治疗 基因疗法 病毒基因 nonviral gene delivery system nonviral gene therapy nonviral gene vectors gene transfer technique gene therapy gene,viral
分类号 R346 [医药卫生—基础医学]
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参考文献17

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同被引文献30

  • 1黄进,汪世龙,孙晓宇,李文哲,姚思德.壳聚糖及其衍生物基因载体的研究进展[J].高分子通报,2006(1):65-69. 被引量：15
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  • 6EICHMAN J D, BIELINSKA A U. The use of PAMAM dendrimers in the efficient transfer of genetic material into cells [J]. Pharmaceutical Science & Technology Today, 2000, 3(7) : 232 - 245.
  • 7DURAIRAJ C. The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats [J]. Biomaterials, 2007, 28: 504-512.
  • 8MINGLU M, YIYUN C. Evaluation of polyamidoamine (PAMAM) dendrimers as drug carriers of anti-bacterial drugs using sulfamethoxazole (SMZ) as a model drug [ J]. European Journal of Medicinal Chemistry, 2007, 42:93 - 98.
  • 9KIM T, BAEK J. Synthesis and characterization of a novel arginine-grafted dendritic block copolymer for gene delivery and study of its cellular uptake pathway leading to trattsfection [J], Bioconjugate Chem, 2007, 18: 309- 317.
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军事医学科学院院刊
2003年 第5期

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