加味丹参饮预处理对缺血再灌注损伤家兔心电图改变的影响

Effect of Jiaweidanshenyin Preconditioning on the Electrocardiograph of Rabbits with Ischemical Reperfusion Injury

目的 :探讨加味丹参饮预处理对缺血再灌注损伤家兔心电图的影响。方法 :将健康家兔 32只 ,随机分为假手术组 (Sham)、缺血再灌注组 (I/R)、药物预处理组 (DP)和缺血预处理组 (IP) ,每组 8只 ,分别预处理 2 4h后行心肌缺血 6 0min、再灌注 12 0min ,观察家兔心率、Ⅱ导联心电图ST段等的变化。结果 :I/R家兔标准Ⅱ导联心电图心率明显减慢、ST段明显抬高或T波倒置 ,并且绝大部分家兔出现心律失常 (87.5 % ) ;而药物预处理和缺血预处理对ST段抬高或T波倒置以及心律失常有明显的改善作用 (P <0 .0 5 ) ,对心率变化作用不明显 (P >0 .0 5 )。结论

Objective: To observe the effect of Jiaweidanshenyin preconditioning on the Electrocardiograph (ECG)of rabbits with ischemical reperfusion injury. Methods:Thirty-two chronically instrumented conscious rabbits successfully underwent the following protocol. Rabbits were randomly divided into four groups: Sham (saline, duodenum), I/R (saline, duodenum), DP (Jiaweidanshenyin, 5.86g/kg,duodenum), IP (four 5-min coronary artery occlusion / 10-min reperfusion cycles). On two day (24h later), rabbits(except the Sham's) underwent a 60-min coronary artery occlusion and 120-min reperfusion. The standard Ⅱ lead ECGs were determinated. Results:There were the markedly decreased cardiac rate, the elevated ST segment of the standard Ⅱ lead ECG in I/R group. Jiaweidanshenyin preconditioning and ischemia preconditioning could markedly antagonize the changes of the ECG and adjust the arrhythmia of the rabbits. Conclusion:Jiaweidanshenyin preconditioning is effective to adjusted the changes of the ECG of rabbit induced by ischemical reperfusion injury.