γ分泌酶 早老素及其相互关系的研究进展
摘要
Alzheimer氏病 (AD)是一种常见的老年相关疾病 ,一个显著的病理特征是病人的脑组织在镜下可见老年斑 [2 ,3 ,4]。γ分泌酶剪切 APP产生的 Aβ42片段是形成老年斑的主要物质。有研究表明早老素 (Presenilin,PS)基因的错义突变可导致 APP异常转运和加工 ,是家族性 AD(FAD)最常见的病因。本文对当前 γ分泌酶 。
基金
湖南省卫生厅资助项目(B2 0 0 3- 1 0 0)
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