蛇菰抗酒毒的实验研究

Experimental Study of Balanophora Japonica Mokino on Resisting Alcohol Toxicity

目的 :了解民族药蛇菰的解酒毒作用。方法 :采用毒理和生化方法检测蛇菰的安全性及其解酒毒后小白鼠的死亡率和血中乙醇浓度的变化 ,观察蛇菰对修复酒精性肝损害的病理变化。结果 :蛇菰小白鼠最大耐受量 >37 5g/ (kg·d) ,相当于成人用量 0 5g/ (kg·d)的 75倍以上 ,安全无毒。可以降低小白鼠酒精中毒的死亡率。蛇菰解酒后小白鼠血中乙醇与对照组比较 ,差异有显著性 (P >0 0 5 ) ,而葛根与蛇菰血中乙醇浓度无差异 (P >0 0 5 )。病理组织学揭示蛇菰能减少酒精性肝损害的肝变性、坏死。结论 :蛇菰具有解酒毒作用 。

Objective: To explore the action of resisting alcohol toxicity of Balanophora Japonica Mokino. Method: Toxicological and biochemical methods are used to observe the safety of Balanophora Japonica Mokino, the dead rate in mice, the change of alcohol, the pathological change of liver tissue which injured by alcohol. Result: The maximal tolerance dose of Balanophora Japonica Mokino in mice is 37.5g/(Kg.d). It is rather safe and can decrease the dead rate for alcoholic toxicity. Compared with control group , the alcohol concentration in blood of Balanophora Japonica Mokino group is remarkable lower(P<0.05). Compared with the Gegeng group, There is no remarkable difference. Pathological change show that Balanophora Japonica Mokino can decrease liver cell degeneration and alcoholic acute liver injury. Conclusion: Balanophora Japonica Mokino can resist alcohol toxicity