不同方法输注氟脲嘧啶、亚叶酸钙联合奥沙利铂治疗晚期消化道肿瘤的临床研究

Clinical Research of Different Infusion of 5-fluorouracil, Leucovorin and Oxaliplatin in Patient with Advanced of Gastrointestinal Carcinoma

目的:比较氟脲嘧啶(5-FU)不同输注法联合亚叶酸钙、奥沙利铂对晚期消化道肿瘤疗效及不良反应。方法:76例晚期消化道肿瘤患者随机分成A、B2组,A组36例,5-FU采用双周疗法;B组40例,5-FU采用持续5天滴注疗法。结果:A组CR 6例(胃癌4例、大肠癌2例),PR 18例(胃癌8例、大肠癌10例),总有效率66.67％(胃癌75％、大肠癌60％)。B组CR 4例(胃癌3例、大肠癌1例),PR 12例(胃癌5例、大肠癌7例),总有效率40％(胃癌44.44％、大肠癌36.36％),二组比较有显著性差异(P<0.01)。主要副作用有:白细胞数下降、感觉神经毒性、口腔粘膜炎、腹痛及腹泻等,A、B 2组相比无显著性差异(P>0.05)。结论:5-FU双周疗法联合亚叶酸钙、奥沙利铂较持续5天滴注疗法有效率明显提高,且未增加不良反应。

Objective: Research has been done to show curative effect and toxicity of different infusion of 5-fluorouracil, leuco-vorin and oxaliplatin in patient with advanced of gastrointestinal carcinoma. Methods: 76 patients were enrolled in this study, 5-FU is given through a catheter in the venae subclavia by continuous infusion for 48 catheter in the venae subclavia by continuous infusion for 120 hours. Results: Objective response rate was observed. A group was 66. 67% of patients ( gastric carcinoma 75% , colorectal carcinoma 60% ) with 6 complete responders ( CR) ( gastric carcinoma 4, colorectal carcinoma 2 ) and 18 partial responders ( PR) ( gastric carcinoma 8, colorectal carcinoma 10) , and 40% in B group ( gastric carcinoma 44. 44% , colorectal carcinoma 36. 36% ) with 4 CR (gastric carcinoma3, colorectal carcinoma 1) and 12 PR (gastric carcinoma 5, Colorectal carcinoma 7) (P <0. 01). All the side effects include bone marrow suppression, mucositis, diarrhea, et al. Conclusions: It showed increased response rate that comparison of 5-FU continuous infusion 48 hours with 120 hours for gastrointestinal carcinoma. It is safe.