口服或阴道用米索前列醇用于人工流产术前宫口扩张的比较

Comparison of misoprostol via oral or vagina in cervical dilatation before artificial abortion

目的 :比较在人工流产术前阴道或口服用米索前列醇后宫口扩张的临床效果。方法 :将 16 1例行人工流产术的早孕妇女分成 3组。第 1组 5 3例和第 2组 5 7例于术前 1h分别经阴道用米索前列醇和口服米索前列醇各 4 0 0 μg ,第 3组为对照组5 1例 ,术前不用任何药物。结果 :第 1组和第 2组宫口扩张有效率分别是 92 % (49/ 5 3)和 89% (5 1/5 7) ,明显高于对照组 0 (0 / 5 1,P <0 .0 1) ;前 2组术中无需使用局部麻醉 (0 / 5 3和 0 / 5 7) ,而对照组则有 74 % (38/ 5 1)的病人需加用局部麻醉 (P <0 .0 1) ;前 2组术中出血量为 (7±s 4 )mL和 (7± 3)mL ,也少于对照组 (12± 4 )mL ,差异有非常显著意义 (P <0 .0 1)。阴道用米索前列醇组与口服米索前列醇组相比 ,术中扩宫口作用差异无显著意义 (P >0 .0 5 ) ,但口服用药组不良反应多于阴道用药组。结论 :阴道用米索前列醇组、口服米索前列醇组术中扩宫口作用肯定 ,出血量小、不良反应轻 。

AIM: To compare the effect via oral or vagina of misoprostol on cervical dilatation before artificial abortion. METHODS: One hundred and sixty one pregnant women were divided into three groups.In group 1, fifity three early gravid women received misoprostol 400 μg via vagina and in group 2 fifty seven early gravid women rceived the same doses of misoprostol oraly 1 h before operation. In control group abortion was performed on fifity one early gravid women without using any drugs before operation. RESULTS: The rates of dilatation of uterus cervix in group 1 and group 2 were 92%(49/53) and 89%(51/57) respectively,higher than those in control group(0/51). The differences were significant( P <0.01).No local anesthsia needed (0/53 vs 0/57)in the former two groups, while 74% of women in control group received local anesthesia, that was significantly higher than that in group 1 and group 2 ( P <0.01).And the amount of hemorrhage of the former two groups during operation was (7± s 4) mL and (7±3) mL respectively, fewer than that of the control group(12±4) mL ( P <0.01). The dilatation effect of misoprostol on cervix was no different between group 1 and group 2 ( P >0.05). But more adverse reactions were found in the women with misoprostol orally than those via vagina. CONCLUSION: Vaginal or oral misoprostol characterizes with confirm effect, small hemorrhage, mild adverse reaction and convenience and safe practice.Both clinical effects are simlar.