苯妥英合成路线改进

Improved-Synthesis Process Route of Phenytoin Sodium

以VB1为催化剂,选择适宜浓度的NaOH溶液,提高安息香收率;以NaNO2、AC2O为氧化剂氧化安息香,可简化操作、缩短时间,提高二苯乙二酮的质量及收率。

By taking VB1 as catalyst and selecting the NaOH solution with the proper concentration,it is to improve the obtained rate of Benzoic acid. On the other hand the quality and yields of diphenlethandione are also inereased and the operation way becomes easier,the reaction time is cut off by using NaNO2 and Ac2O as oxidizers.