氧化苦参碱治疗慢性乙型肝炎远期疗效观察

Remote effect of oxymatrine on chronic hepatitis B

目的 探讨氧化苦参碱治疗慢性乙型肝炎的远期疗效。方法 将慢性乙型肝炎患者 2 38例随机分为 2组 ,治疗组予氧化苦参碱注射液肌肉注射 ,90d为 1个疗程。对照组予α-干扰素针剂肌肉注射 ,6～ 10个月为 1个疗程。疗程结束后随访 1年。结果 治疗结束 1年后 ,治疗组ALT及SB复常率分别达 79.4 %和 6 9.8% ,HBeAg阴转率达 4 5 .6 % ,HBV -DNA阴转率达 4 4 .9% ,与对照组比较无明显差异 (P >0 .0 5 )。结论 氧化苦参碱治疗慢性乙型肝炎具有价廉、无毒、效佳的特点 ,远期疗效确切 。

Objective It is to evaluate the remote effect of oxymatrine on chronic hepatitis B. Methods 238 patients with chronic hepatitis B were divided into two groups at random. The treatment group were treated with oxymatrine intramuscular injection for 90 days, while the control group were treated with IFN-α intramuscular injection for 6 to 10 months. All were followed up for a year after therapy. Results One year after therapy, ALT recovery rate and SB recovery rate in the treatment group respectively were 79.4% and 67.8%. HBeAg turn to negative rate in treatment group was 45.6%. HBV-DNA turn to negative rate was 44.9%. There was no significant difference between two groups ( P >0.05). Conclusion Oxymatrine is cheap, safe, and effective and has exact curative effect on chronic hepatitis B.