原发性肝癌与乙型肝炎病毒感染的关系

Hapatocarcingenesis and Hepatitis B Virus Infection

目的探讨HBV感染模式与肝病的关系.方法选择经检测HBV 5项血清学标志的肝癌患者120例为研究对象,并以非癌肝病180例作对照.结果 120例肝癌患者HBV感染以HbsAg 75.1%(90/120),抗-Hbe 70.2%(84/120),抗-Hbc 80.5%(97/120)为主.与对照组58.9%,48.3%,66.1%比较,差异非常显著(P<0.01).肝癌组HBV总感染率高达98.3%.感染模式以HbsAg,抗-Hbe,抗-Hbc;HbsAg,抗-Hbc;抗-Hbe,抗-Hbc;HbsAg,HbeAg,抗-Hbc四种为主,占83.3%(100/120).肝炎、肝硬化、肝癌的HBV感染主要模式一致.结论 HBV是肝癌的主要原因之一,尤其4种感染模式与肝癌发生密切相关,定期随访复查是发现早期肝癌的最佳途径.

ObjectiveTo study the serum HBV marks and their relations to liver diseases.Methods120 cases with serum HBV marks of HCC and 180 cases with non-cancer liver diseases were tested.Results3 main HBV marks in HCC were HbsAg((75.1%)), anti-Hbe((70.2%)) and anti-Hbc((80.5%)) and those in non-cancer liver diseases were HbsAg((58.9%)), anti-Hbe((48.3%)) and anti-Hbc((66.1%)); there was a significant difference(_P_<(0.01)) in the 3 main HBV marks between HCC and non-cancer liver diseases. 4 main HBV marker in HCC were as follows: HbsAg, anti-Hbe, anti-HBc; HbsAg, anti-HBc; anti-HBe, anti-HBc; HbsAg, HbeAg, anti-Hbc, and they accounted for (83.3%). The HBV marker mothods in HCC were consistent with those in haptitis and cirrhosis.ConclusionHBV infection is a main factor of liver cancer. 4 main HBV marker methods are closely related to hapatocarcingenesis. Periodic follow-up reexamination for hepatitis and cirrhosis are the best ways to discover early-stage HCC.