老年性痴呆发病机制的研究进展

Research progress in the Alzheimer disease pathogenesis

老年性痴呆的发病机制十分复杂 ,包括早老素等遗传基因的突变、异常过度磷酸化的tau蛋白引起的细胞骨架改变、脑内乙酰胆碱含量减少等中枢神经系统递质代谢障碍、淀粉样前体蛋白代谢失调引起的细胞外老年斑的形成、细胞内钙代谢紊乱、免疫炎症反应、自由基损伤学说和神经细胞凋亡等发病机制 。

Alzheimer disease pathogenesis is complicated,including Presenilin gene genetic mutation,abnormal over-phosphated Tau protein resulting in cytoskeleton changes,central nerve system neurotransmitter metabolism disorders such as acetylcholine decreasing,amyloid precursor protein metabolism disorder leading to senile plaque formation extracellular, intracellular calcium metabolism disorder,immune inflammation response,free radical damage hypothesis and neuron apoptosis leading to neuron loss and so on,as follows go into the details of Alzheimer disease pathogenesis of all kinds.