摘要
目的 :观察二硝酸异山梨酯 (ISDN)静脉滴注对不稳定型心绞痛 (UAP)患者血小板表面P 选择素表达的影响及其量效关系。方法 :选择 5 1例不稳定型心绞痛患者为研究对象 ,随机单盲分为 3组 ,分别给予ISDN 2 ,4 ,8mg/h静滴。采用流式细胞仪测定用药前 10min及用药后 2 ,8h血小板表面P 选择素的表达。结果 :不稳定型心绞痛患者血小板P 选择素表达明显高于健康对照组。ISDN 2mg/h组用药后 2h即观察到血小板表面P 选择素表达的抑制 (P <0 .0 5 ) ,而且抑制作用随给药的剂量和时间的增加而增强。结论 :静脉滴注一氧化氮供体可以抑制血小板表面P 选择素的表达并存在剂量依赖关系。
Objective: Our aim was to investigate the influence of isosobide dinitrate on expression level of P selectin and dose effectiveness relationship.Methods:Fifty one patients with unstable angina were randomly and single blindly divided into 3 groups. Isosobide dinitrate (ISDN) was intravenously injected at 2,4,and 8mg/h. Flow cytometry technique was used to analyze the expression of P selectin. Results:The expression of P selectin in patients with unstable angina was significantly higher than that in healthy controls. Two hours after the injection of ISDN, the expression of P selectin was greatly inhibited(P<0.05),and the inhibitory effect was increased with the time and dosage increased. Conclusion:Nitric oxide can inhibit expression of human platelet P selectin dose dependently.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2003年第6期530-531,共2页
Journal of China Medical University
基金
辽宁省科技攻关项目 (2 0 0 12 2 5 0 0 1-18)
