绵羊绝经后骨质疏松动物实验模型的建立

Studies on sheep as osteoporosis animal model

目的:寻找并建立一种简便、经济、有效、可靠的大动物绝经后骨质疏松模型,为在骨质疏松状态下进行骨融合牙种植体生长状况的实验研究创造基础.材料与方法:5岁与7岁生育哺乳期后绵羊各一只行卵巢切除术,于卵巢切除术前及术后半年测量腰椎骨密度,测量血碱性磷酸酶、钙元素、骨钙素含量.结果:两只绵羊在去势手术后,腰椎骨密度均明显下降,血碱性磷酸酶、血钙、骨钙素含量均升高.结论:生育哺乳期后的绵羊可能是一种简便、经济、有效、可靠的大动物骨质疏松模型.

Objective: Try to find a kind of feasible, economic, effective big animal model for osteoporosis. Methods: Two ewes (one is 5 years old, the other is 7 years old. The two had completed weaning their last young.) were ovariectomized bilaterally. Before OVX and 6 months after OVX, lumbar BMD was measured, blood samples were collected to determine the level of serum ALP, BGP, Ca. Results: the two ewes' lumbar BMD decreased significantly. There was significant increase of ALP, BGP, Ca after OVX. Conclusions: Ewe may be a kind of feasible, economic, effective big animal model for osteoporosis.