β-胡萝卜素微囊的制备

Preparation of β Carotene Microcapsules

目的：为提高β－胡萝卜素（β－ｃａｒｏｔｅｎｅ，β－Ｃ）稳定性。方法：采用复凝聚法制备微囊，以光照试验进一步考察β－Ｃ微囊的稳定性。结果：β－Ｃ溶液于室温、见光放置下的药物半衰期仅０．８２天，而室温、避光放置１个月基本稳定。β－Ｃ原料药于光照条件下半衰期为６．９天，而β－Ｃ微囊在相同条件下半衰期为２４．８天，β－Ｃ微囊为原料药的３．６倍。结论：光线是影响β－Ｃ稳定性的重要因素，将β－Ｃ制成微囊可增加药物制剂的稳定性。

Objective:To raise the stability of β carotene with preparation of microcapsules. Methods:β carotene microcapsules were prepared with phase separation coacervation. The stability of light exposure of β carotene and it's microcapsules were investigated with illumination test. Results:The half life was only 0.82 day on exposure to light of β carotene in solution and one month if protected from light at room temperature. The half lives of raw material and β carotene microcapsules by illumination test were 6.9 and 24.8 days respectively. Conclusion:The stability of exposure to light of β carotene can be raised by drug microcapsulation.