先天性室间隔缺损患儿血浆血栓素、前列环素含量与肺动脉高压的关系

Relationship between Plasma Levels of TXA 2、PGI 2 and Pulmonary Artery Hypertension in Congenital Ventricular Septal Defect

目的：研究先天性室间隔缺损（先心室缺）患儿血浆血栓素（ＴＸＡ２）、前列环素（ＰＧＩ２）与肺高压的关系。方法：以心导管术或手术前直接测压法测定２８例先心室缺患儿的肺动脉压，采用放射免疫法测定其血浆中ＴＸＡ２、ＰＧＩ２的稳定代谢产物血栓素Ｂ２（ＴＸＢ２）、６－酮－前列腺素Ｆ１α（６－ｋｅｔｏ－ＰＧＦ１α）的水平，以了解ＴＸＡ２、ＰＧＩ２的浓度变化。以１０例正常儿童为对照组。结果：①与对照组比较，正常肺动脉压组（ＮＰＡＰ）血浆ＴＸＢ２、ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α无显著改变，而６－ｋｅｔｏ－ＰＧＦ１α则显著降低；肺高压组（ＰＡＨ）ＴＸＢ２、ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α均显著升高。而６－ｋｅｔｏ－ＰＧＦ１α与之相近；②与ＮＰＡＰ比较，ＰＡＨ组ＴＸＢ２、ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α显著升高，而６－ｋｅ－ｔｏ－ＰＧＦ１α虽有升高，但无显著意义。结论：血浆ＴＸＡ２。

Objective:To investigate the relationship between plasma levels of TXA 2、PGI 2 and pulmonary artery hypertension in children with congenital ventricular septal defect (VSD).Method: The pulmonary pressure of 28 cases with congenital VSD was determined by catheterization or directly determined before surgery and the plasma levels of TXB 2、6 keto PGF 1α (the metabolites of the TXA 2、PGI 2) were determined by the RIA.Ten healthy children were used as the control group.Results:①Compared with the control group,in normal pulmonary artery pressure group (NPAP),the plasma levels of TXB 2、TXB 2/6 keto PGF 1α showed no significant change,but the level of 6 keto PGF 1α was significantly lower;in pulmonary artery hypertension group (PAH),the plasma levels of TXB 2 and TXB 2/ 6 keto PGF 1α were significantly increased,but the level of 6 keto PGF 1α was nearly normal.②Compared to the NPAP,the plasma levels of TXB 2,TXB 2/6 keto PGF 1α of the PAH were significantly increased,while the level of 6 keto PGF 1α was increased,but without statistical significance.Conclusion:The imbalance between plasma levels of TXA 2、PGI 2 may contribute to the course of pulmonary artery hypertension.