黄芪多糖对肉鸡脾淋巴细胞转化及信息分子的影响

Effect of astragalan on lymphocyte proliferation and signal molecules in the spleen of broilers

本实验研究了黄芪多糖对肉鸡脾淋巴细胞转化率及细胞内信息分子 -一氧化氮 (NO)、Ca2 + 及 c AMP、c GMP的影响。发现黄芪多糖能剂量依赖性促进脾淋巴细胞转化率及细胞内 NO、Ca2 + 浓度 ;当作用时间为 2 0 min时 ,4 0 μg/ ml黄芪多糖能增加 c AMP浓度 ,降低 c GMP浓度 (P<0 .0 1) ;而当作用时间为 6 0 m in,对 c AMP和 c GMP浓度无显著影响。以上结果提示 ,黄芪多糖能显著提高脾淋巴细胞免疫功能 ,其作用是通过改变细胞内信息传导实现的。

This research was conducted to study the effect of astragalan on splencytes proliferation and signal molecule like NO,Ca^(2+),cAMP and cGMP. The results showed that astragalan increased splencytes proliferation and the contents of NO and Ca^(2+) in similar dose dependent manner. It increased cAMP but decreased cGMP content when the treatment time was 20 min, but had no effect when the treatment time was 60 min.