肝动脉插管化疗栓塞与联合电化学治疗肝癌的疗效比较

The comparison of effect in the treatment of advanced liver cancer between the transhepatic arterial chemoem-bolization with electrochemical treatmert and the transtepatic arterial chemoembolization alone

目的:对肝动脉插管化疗栓塞(TACE)联合电化学治疗(ECT)与单纯采用TACE治疗中晚期肝癌的疗效进行比较.方法:将40例失去手术机会的中晚期肝癌患者随机分成A、B两组.A组在TACE间期配合ECT治疗,B组单纯接受TACE治疗.结果:A组有4例完全缓解(CR),12例部分缓解(PR),CR+PR为80%.有7例获得二期手术切除,1年存活率65%.甲胎蛋白(AFP)从治疗前的752.18±423.39μg/L降至206.28±189.24μg/L.B组有1例CR,9例PR,CR+PR 50%.有3例获得切除,1年存活率 40%.AFP从治疗前的782.61±491.23μg/L降至411.26±325.17μg/L.两组有效率(PR+CR)及切除率有显著差异(P<0.05).结论:TACE联合ECT治疗中晚期肝癌的疗效优于单纯的TACE治疗.

Objective:To evaluate the effect of the transhepatic arterial chemoembolization(TACE) plus electrochemical treat-ment(ECT) and TACE alone in the treatment of advanced liver cancer. Methods:40 patients with unresectable liver cancer were di-vided into group A and group B randomly. Patients of group A were treated with the combination of TACE and ECT. Patients of group B were treated with TACE alone. Results: In group A, 4 patients were complete remission(CR), 12 patients were partial re-missiom (PR). The overall effective rate was 80% . 7 patients with unresectable liver cancer converted to resectable ones. The one year survial rate was 65 % . Alpha fetu protein (AFP) declined from 752.18 ?423.39礸/L to 206.28 ?189.24礸/L after teatment. In group B, only one patient was CR, 9 patients were PR, CR + PR was 50%. AFP declined from 782.61 ?91.23/礸/L to 411.26 ?325.17礸/L after treatment. The one year survial rate was 40% . Conclusion: The combination of TACE and ECT was more ef-fective than TACE alone in the treatment of advanced liver cancer.