肝癌及其癌周组织与胃癌患者肝组织中性激素受体的研究

The difference in the distribution between sex hormone receptor among liver cancer, surounding tissue of liver cancer and normal liver tissue of gastric carcinoma.

目的:研究肝癌组织中性激素受体分布的差异及其意义.方法:以放射性配基结合分析法(RBA)测定了63例行手术切除的肝癌组织、癌周组织及7例非肝癌肝组织的性激素受体的含量并进行统计分析.结果:(1)肝癌组织及其癌周组织与胃癌患者癌肝组织的胞浆和胞核中存在性激素受体,且胞核中性激素受体的含量明显高于胞浆.(2)非肝癌肝组织的胞浆和胞核中性激素受体的含量:孕激素受体>雌激素受体>雄激素受体.(3)肝癌组织与癌周组织的胞浆和胞核中性激素受体的含量:雄激素受体>孕激素受体>雌激素受体.结论:肝癌的发生可能与肝癌组织中雄激素受体含量的升高和孕激素受体含量的降低有关.

Objective: To explore the difference and significance among the sex hormone receptors in the liver cancer tissue. Methods: Receptor binding assay (RBA) was adopted to measure the distribution of sex hormone receptor (SHR) in liver cancer and tissue in its vicinity in 63 patients with primary liver cancer undergone laparotomy and in normal liver tissue in 7 cases with gastric carcinoma. Results:(1) SHR was demonstrated in the liver cancer tissue and surrounding non- tumorous tissue, and the non-tumor liver tissue. The concent of SHR in the nucleus was siginificantly higher than that in the cytoplasm. (2)The concent of SHR in non - tumor liver: Progesterone Receptor>Estrogen Receptor> Androgen Receptor. (3)The concent of SHR in liver cancer and tissue in its vicinity: Androgen Receptor > Progesterone Receptor > Estrogen receptor.Conclusion: The development of Some liver cancer probably has relationship with higher Androgen Receptor and lower Progesterone Receptor.