摘要
The effects of the domestically manufactured contraceptive, Sino implant containing LNG on various lipids, lipoproteins, apolipoproteins and the HDL 2 C levels were evaluated in 20 healthy reproductive aged volunteers, during cycles after implantation. Results show that the levels of lipids, lipoproteins and apolipoproteins were reduced to different degrees during the 12 treatment cycles. A significant decrease was observed in the serum levels of triglycerides (TG, P<0.05) and apolipoprotein AⅠ (apo AⅠ , P<0.05) during treatment cycles. However these values increased again at the end of the 12th cycle. High density lipoprotein 2 cholesterel (HDL 2) decreased significantly (P< 0.05), only during the 3rd and 12th cycle. These results indicate that Sino implants containing LNG exerts an influence on reducing the levels of TG, apo AⅠ and HDL 2, but those values could return gradually as the released drug dose decreased and then became unchanged. On the other hand, the mechanism of the low HDL 2 C level induced by Sino implant is different from that of low HDL 2 C level in patients with coronary heart disease. The conclusion is: there is no obvious side effect on lipid metabolism during treatment with the Sino implant.
The effects of the domestically manufactured contraceptive, Sino implant containing LNG on various lipids, lipoproteins, apolipoproteins and the HDL 2 C levels were evaluated in 20 healthy reproductive aged volunteers, during cycles after implantation. Results show that the levels of lipids, lipoproteins and apolipoproteins were reduced to different degrees during the 12 treatment cycles. A significant decrease was observed in the serum levels of triglycerides (TG, P<0.05) and apolipoprotein AⅠ (apo AⅠ , P<0.05) during treatment cycles. However these values increased again at the end of the 12th cycle. High density lipoprotein 2 cholesterel (HDL 2) decreased significantly (P< 0.05), only during the 3rd and 12th cycle. These results indicate that Sino implants containing LNG exerts an influence on reducing the levels of TG, apo AⅠ and HDL 2, but those values could return gradually as the released drug dose decreased and then became unchanged. On the other hand, the mechanism of the low HDL 2 C level induced by Sino implant is different from that of low HDL 2 C level in patients with coronary heart disease. The conclusion is: there is no obvious side effect on lipid metabolism during treatment with the Sino implant.
