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应用组织芯片技术对外阴尖锐湿疣和鳞状细胞癌关系的研究 被引量：1

Analysis of the Relationship between Vulva Condyloma Acuminatum and Squamous Cell Carcinoma by Tissue Microarray
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摘要 为探讨外阴尖锐湿疣和鳞状细胞癌之间的关系 ,使用组织芯片和免疫组织化学技术观察 2 2 7例外阴尖锐湿疣和 2 1例外阴鳞状细胞癌 HPV16/ 18、p5 3、PCNA的表达 ,并进行了分析。结果显示 ,HPV16/ 18阳性外阴尖锐湿疣 p5 3、PCNA的阳性指数、吸光度与 HPV16/ 18阴性者差异有显著性 ,与鳞状细胞癌也有显著差异 ;HPV16/ 18阳性外阴尖锐湿疣的 PCNA表达率与鳞状细胞癌无显著差异。
作者 孙莉 李新功 徐志秀 许金萍 吴起嵩 董艳光
机构地区 胜利石油管理局中心医院皮肤科 胜利石油管理局中心医院病理科
出处 《数理医药学杂志》 2003年第6期499-501,共3页 Journal of Mathematical Medicine
关键词 组织芯片技术 外阴尖锐湿疣 鳞状细胞癌 增殖细胞核抗原 免疫组织化学 分子原位杂交
分类号 R752.53 [医药卫生—皮肤病学与性病学] R737.34 [医药卫生—肿瘤]
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参考文献7

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二级参考文献20

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共引文献84

同被引文献10

  • 1孟奎,石群立,马恒辉,周晓军,夏春,周洁.组织芯片制备新方法[J].医学研究生学报,2005,18(3):287-288. 被引量：5
  • 2张巧英,姚根有.石蜡组织芯片的制备方法及技巧[J].实用肿瘤杂志,2005,20(6):551-553. 被引量：4
  • 3蒋会勇,张三泉,张进华,陈愉,赵彤.国产石蜡制作组织微阵列的探索及应用评价[J].第四军医大学学报,2006,27(1):93-94. 被引量：9
  • 4陈煊,李邻峰.应用组织芯片技术研究光暴露皮肤与非光暴露皮肤中PCNA的表达[J].中国麻风皮肤病杂志,2006,22(9):713-715. 被引量：1
  • 5黄卡特,杨开颜,张虎祥.手工制作组织芯片在HPV原位杂交中的应用与体会[J].实用医学杂志,2007,23(6):932-932. 被引量：2
  • 6Kononen J,Bubendorf L,Kallioniemi A,et al.Tissue microarrays for high-throughput molecular profiling of tumor specimens.Nat Med 1998;4(7):844-847.
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  • 8Korabiowska M,Cordon-Cardo C,Jaenckel F,et al.Application of in situ hybridization probes for MLH-1 and MSH-2 in tissue microarrays of paraffin-embedded malignant melanomas:correlation with immunohistochemistry and tumor stage.Hum Pathol 2004;35(12):1543-1548.
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  • 10Welsh JB,Zarrinkar PP,Sapinoso LM,et al.Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer.Proc Natl Acad Sci USA 2001;98(3):1176-1181.

引证文献1

数理医药学杂志
2003年 第6期

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