摘要
对25例慢性肾功能不全贫血病人(IR液透析维持状态15例,非透析病人10例)用重组人促红细胞生成素(r-HuEPO)治疗6个月并进行了观察,用r-HuEPO 6～9周后有23例病人Hb达到理想水平,平均Hb 106±8 g/L,hct 0.331±0.029。透析病人和非透析病人各1例用r-HuEPO后无效。5例合并血小板减少和3例合并白细胞减少的病人用r-HuEPO 12周后各有1例恢复正常。病人一般症状明显好转。贫血改善后病人平均动脉压升高,血液透析病人用r-HuEPO前为12.5±2.39 kPa(94±18mmHg),用r-HuEPO 3个月时上升至14.36±0.74 kPa(108±5.6 mmHg,P<0.05);非透析病人用r-HuEPO前为12.77±2.26 kPa(96±17mmHg),用r-HuEPO 3个月时为14.89±0.89 kPa(112±6.7mmHg,P<0.05)。病人内生肌酐清除率、血肌酐、尿素氮、钙、磷、尿酸、24h尿蛋白定量在用r-HuEPO后3个月和6个月与用r-HuEPO前无显著改变。
25 anemia patients caused by chronic renal insufficiency, 15 patients kept haemodialy- sis, the other received nondialysis treatment, were given recombinant human erythropoietin (r-HuEPO) thrice a week intravenously. Haemoglobin(Hb) rose to 106±8 g/L in 23 cases after 6~8 weeks accompanying increased life quality. 1 of 5 eases with low platelets counts and 1 of 3 cases with low leukocytes returned to normal 12 weeks after r-HuEPO adminis- tration. Mean WBC and platelets counts increased 12 weeks after r-HuEPO therapy. Mean blood pressure increased while haemoglobin rose. No significant changes were found in serum creatinine, uria, calcium, phosphorus, uric acid, cretinine clearance and 24h proteinurea amount.
