创伤性脊髓损伤病人的固体胃排空及吗丁啉的治疗观察

Gastric Emptying of Solids and Analysis of Therapeutic Efficacy of Domperidone in Traumatic Spinal Cord Injury

观察了完全性脊髓损伤病人16例(高位6例、低位10例)的固体胃排空情况,及吗丁啉对延迟胃排空的疗效。发现高位脊髓损伤组(HSCI)餐后3.5及5 h胃排空(GE)明显延迟(P<0.001),低位脊髓损伤组(LSCI)无明显延迟(P=0.053),凡GE延迟者,胃窦的运动减弱、减慢。口服吗丁啉后GE明显改善(P<0.05)。

The aim of this study was to investigate the gastric emptying (GE)of solids in patients with complete spinal cord injury(SCI) and to observe the therapeutic efficacy of DOMPERI- DONE (DOM) on delayed GE. Sixteen patients (6 high-cord, 10 low-cord) and 10 heslthy controls were studied. Radiopaque markers for studying GE were used, the markers retained in the stomach were counted and antral contractions were observed as well. Five patients with delayed GE took DOM 20 mg T.I.D.for 1 week, then the GE repeated. The GE was markedly delayed at 3. 5 and 5 h postprandially in high-cord group compared with controls (P<0. 001) but no significant difference was seen in low-cord group at 5 h postprandially (P=0. 053). All the patients with delayde GE had decreased antral motility. After the oral administration of DOM the GE was greatly improved (P<0. 05). We conclude that high- cord patients(above T_5) have delayed GE of solids, partial low-cord (below T_(10))delay also, and DOM accelerates the GE.