钠离子通道与蜜蜂狄斯瓦螨对氟胺氰菊酯的抗性机理

Advances in research of fluvalinate resistance in Varroa destructor: sodium channels involved.

狄斯瓦螨Varroadestructor是全世界蜜蜂最严重的寄生虫 ,目前 ,它对主要防治药物———拟除虫菊酯类的氟胺氰菊酯已产生明显抗性 ,严重影响其防治效果。近年来神经生理学研究结果证实 :电压门控的钠离子通道是拟除虫菊酯作用的位点。钠通道结构的改变 ,是拟除虫菊酯类杀虫剂毒理的主要基础 ,也是产生抗药性的基础。该文介绍了近年来国内外研究电压门控钠离子通道、拟除虫菊酯对钠通道的作用。

Varroa (Varroa destructor) is an ectoparasite of honeybee and distributed worldwide. The beekeeping industry around world has been severely impacted by the mite. Tau fluvalinate, a pyrethroid insecticide is routinely used to control this mite. Unfortunately, varroa recently developed resistance to tau fluvalinate in the world .Genetic and biochemical studies have contributed to our understanding of pyrethroids resistance. Recent study shows that Target site (sodium channel)insensitivity emerged as one of the most important pyrethroid resistance mechanisms in many insect species. In this paper voltage sensitive sodium channels, action of pyrethroids on voltage sensitive sodium channels, sodium channels gene mutation underlies the mechanisms of pyrethroids resistance, advances in research of fluvalinate resisitance in V. destructor are introduced.