晚期肾癌的转移机制及治疗方式

The mechanism of late-stage renal cell carcinoma metastasis and its therapeutic strategy

晚期肾癌又称转移性肾癌,通过血行及淋巴系统转移至全身,总体预后非常差。手术治疗不能治愈晚期肾癌,只能减少肿瘤负荷,而且其对放化疗不敏感。鉴于肾癌属于免疫源肿瘤,且肿瘤血供丰富,目前全身治疗依赖于细胞因子治疗及抗血管生成的靶向治疗。本文从肾癌转移途径,转移机制及治疗方式等方面进行小结。

Late-stage renal cell carcinoma(RCC),also known as metastatic RCC(mRCC),developed distant metastases through hematogenous or lymphatic approaches,and its prognosis is very poor.mRCC resists to radio-or chem-o-therapy and cytoreductive surgery can only serve as an assistant treatment.In view of the fact that RCC is immunoactive and vascular-rich neoplasm,its therapeutic strategy largely depends on cytokine therapy and anti-angiogenesis target therapy.Our goal is to summarize the mechanism of mRCC metastasis and its therapeutic strategy.