小功率钬激光前列腺剜除术在良性前列腺增生治疗中的临床价值

Clinical value of low power holmium laser enucleation in the treatment of prostate for benign prostatic hyperplasia

目的:评价小功率钬激光前列腺剜除术用于良性前列腺增生(BPH)治疗中的临床价值。方法:选择2012年1月~2015年6月收治的BPH患者312例,将患者随机分为2组,观察组(n=156)为行小功率钬激光前列腺剜除术组,对照组(n=156)为行经尿道前列腺电切术组。比较2组手术时间、切除增生重量、术后血清Na^+、血Hb、并发症、导尿管置留时间、住院时间以及术后最大尿流率(Q_(max))、国际前列腺症状评分(IPSS)、生活质量评分(QOL)、血清前列腺特异性抗原(PSA)。结果:两组患者围手术期指标结果显示,观察组切除标本重、血清Na^+、Hb、术后冲洗时间、尿管置留时间、术后住院时间及并发症等与对照组相比较,差异有统计学意义(P<0.05);两组患者术后随访结果显示,观察组3、6及12个月的Q_(max)、IPSS、QOL及PSA与对照组相比较,差异均无统计学意义(P>0.05)。结论:小功率钬激光前列腺剜除术与经尿道前列腺电切术用于治疗BPH疗效相当,且具有并发症发生率低的优点,值得在临床上推广应用。

Objective:To investigate the clinical value of low power holmium laser enucleation in the treatment of prostate for benign prostatic hyperplasia.Methods:312patients with prostate for benign prostatic hyperplasia in our hospital during January 2012 to June 2015 were randomly divided into 2groups:patients in the observation group(n=156)received low power holmium laser enucleation,and those in the control group(n=156)received transurethral resection of prostate.The operation time,removal weight of proliferation,postoperative serum Na+,blood Hb,complications,catheter indwelling time,hospital stay and postoperative maximum urinary flow rate(Qmax),International Prostate Symptom Score(IPSS),quality of life score(QOL),and serum prostate-specific antigen(PSA)were compared between the two groups.Results:The removal weight of proliferation,postoperative serum Na+,blood Hb,washing time after operation,complications,and hospital stay between the two groups were statistically significant(P<0.05).The Qmax,IPSS,QOL and PSA at 3rd,6th and 12 th month after operation between the two groups showed no statistically significant differences(P <0.05).Conclusions:Low power holmium laser enucleation in the treatment of prostate for benign prostatic hyperplasia had similar efficacy to transurethral resection of prostate,and the former had the advantage of lower complication rate,so it was worthy of clinical application.