经尿道前列腺剜除术对良性前列腺增生患者的疗效及对BUN、Scr、NSE、S100β蛋白水平的影响

Curative effectivensss of transurethral enucleation of prostate for benign prostatic hyperplasia and its effects on BUN,Scr,NSE and S100β protein levels

目的:研究电切镜经尿道前列腺剜除术对BPH患者的疗效及对BUN、Scr、NSE、S100β蛋白水平的影响。方法:分析2015年2月～2016年8月收治的104例BPH患者资料。根据前列腺体积、术前尿素氮水平以及肌酐水平等因素按1∶1配对分为观察组与对照组,每组各52例。对照组予以电切镜经尿道前列腺电切术治疗,观察组则予以电切镜经尿道前列腺剜除术治疗。比较两组各项手术指标,手术前后血清BUN、Scr、NSE、S100β蛋白水平,并发症发生情况。结果:观察组术中失血(177.12±84.38)ml,明显低于对照组的(245.29±128.75)ml,前列腺切除体积(49.62±10.29)ml,明显大于对照组的(41.14±8.82)ml,组间比较差异有统计学意义(P<0.05)。术后24h观察组血清BUN、Scr水平分别为(5.59±0.62)mmol/L、(70.28±9.47)μmol/L,均低于对照组的(5.93±0.77)mmol/L、(78.75±10.28)μmol/L,组间比较差异有统计学意义(均P<0.05)。术后24h观察组血清NSE、S100β蛋白水平分别为(6.07±2.04)μg/L、(0.15±0.10)μg/L,与对照组的(6.15±2.08)μg/L、(0.19±0.12)μg/L相比,差异无统计学意义(均P>0.05)。两组术后出血、排尿困难、尿失禁以及勃起功能障碍发生率比较差异不明显,组间比较差异无统计学意义(均P>0.05)。结论:电切镜经尿道前列腺剜除术治疗BPH效果明显,对肾功能影响较小,且不会增加对患者脑组织造成严重损害的概率,具有较好的安全性。

Objective:To study the curative effectiveness of transurethral enucleation of prostate for benign prostatic hyperplasia and its effects on blood urea nitrogen(BUN),serum creatinine(Scr),NSE and S100β protein levels.Methods:104 patients with benign prostatic hyperplasia from February 2015 to August 2016 in our hospital were selected.Patients were divided into control group and observation group according to factors such as prostate volume,preoperative BUN level,and Scr level,by 1:1 and 52 patients in each group.The control group was treated with TURP transurethral resection of the prostate,and the observation group was treated with transurethral enucleation of the prostate.The operative indexes such as BUN,Scr,NSE,S100β protein levels and complications were compared between the two groups before and after operation.Results:The intraoperative blood loss in the observation group was(177.12±84.38)mL,which was significantly less than that in the control group[(245.29±128.75)mL];the volume of prostatectomy was(49.62±10.29)mL in the observation,which was significantly greater than that in the control group[(41.14±8.82)mL],and the difference between the two groups was statistically significant(P<0.05).The levels of BUN and Scr in the observation group were(5.59±0.62)mmol/L and(70.28±9.47)μmol/L respectively,which were significantly lower than those in the control group[(5.93±0.77)mmol/L and(78.75±10.28)μmol/L],and the difference between the two groups was statistically significant(P<0.05).The levels of serum NSE and S100β protein were(6.07±2.04)μg/L and(0.15±0.10)μg/L in the observation group after 24 h,and there was no significant difference between the control group and the control group[(6.15±2.08)μg/L and(0.19±0.12)μg/L respectively](P>0.05).The postoperative hemorrhage,dysuria,urinary incontinence and erectile dysfunction showed no significant difference between the two groups(P>0.05).Conclusions:The curative effectiveness of transurethral enucleation of the prostate for benign prostatic hyperplasia is obvious,and it has little effect on the renal function,does not cause serious damage to the brain tissue,and has good safety.