羟基喜树碱联合化疗方案治疗晚期胃癌的疗效观察

HCPT Combined with Chemotherapy for Advanced Gastric Cancer

目的 观察含羟基喜树碱 (HCPT)的联合化疗方案治疗胃癌的疗效。方法 3 4例胃癌患者采用拓喜(HCPT)加顺铂 (DDP)加 5氟尿嘧啶 ( 5 Fu)加醛氢叶酸钙 (LF)方案进行治疗。结果 完全缓解 (CR) 2例 ,部分缓解(PR) 1 2例 ,有效率 4 1 2 %,毒副反应以骨髓抑制 (白细胞下降 )及消化道反应为重。结论 HCPT +DLF方案治疗胃癌疗效较好 ,毒副反应轻。

Objective To study the therapeutic effects of Hydroxycampothecine(HCPT) combined with chemotherapy for advanced gastric cancer.Methods Thirty-four patients with advanced gastric cancer were treated with HCPT and DLF regimen.Results There were two cases of CR,twelve PR.The total response rate was 41.2%.The major side-effects were depression of bone marrow(WBC↓) and gastrointestinal symptoms and these could be tolerated by the patients. Conclusions HCPT combined with chemotherapy for advanced gastric cancer has better effects and is worth of further study.