宫颈管支原体培养药敏的临床研究

Culture and drug sensitivity of mycoplasmas from cervical canal

目的:了解解脲支原体(Uu)及人型支原体(Mh)在非淋菌性宫颈管炎中的药敏实验的特点及临床意义。方法:选择本科疑诊为宫颈管炎的性病患者,采用南京市黎明生物制品经营部的解脲支原体(Uu)及人型支原体(Mh)培养加药敏的试剂盒,进行Uu及Mh培养加药敏试验的临床研究。结果:400例疑诊为宫颈管炎共检出Uu及Mh阳性患者182例,阳性率为45.5%;其中Uu培养阳性者104例,阳性率为57.14%,Mh培养阳性者78例,阳性率为42.86%,患者中有Uu及Mh混合感染35例,阳性率为19.23%。结论:药敏试验结果显示,其中对红霉素、乙酰螺旋霉素、白霉素、四环素耐药的浓度最高;对强力霉素、美满霉素、氧氟沙星、环丙沙星次之:对氯霉素、强力霉素、交沙霉素耐药的浓度最低。临床医生应引起重视,提示明确的诊断是正确治疗的前提,合理用药,才能有效减少抗生素耐药菌株的产生。

Objective:To explore the characteristics and clinical significance of durg sensitive test of Ureaplasma urea-lyticum(Uu) and Mycoplasma hominis (Mh) from nongonococcal inflammed cervical canal.Methods:Cultures and drug sensi-tive tests of Uu and Mh in 400 patients with sexually transmitted diesases presumably diagnosed as having cervicitis were con-ducted using Uu/Mh assay kit obtained from Liming Biological Products Company in Nanjing.Results:The cultures were posi-tive for Uu and Mh in 182 patients (positive rate 45.5%),of whom 104 had infection of Uu(positive rate 57.14%),78 hadinfection of Mh (positive rate 42.86%),and 35 had mixed infection of Uu and Mh(positive rate 19.23%).Conclusions:Drug sensitive tests showed that the mycoplasmas were most resistant to erythromycin,acetylspiramycin,kitasamycin,and tet-racycline,followed by minocycline,ofloxacin,and ciprofloxacin,and were least resistant to chloromycin,doxycycline,andjosamycin.This fact suggests the importance of micrological diagnosis and drug sensitive test before antibiotic usage.